Duesbery, Nick, Ph.D.

Dr. Duesbery received both his M.Sc. (1990) and Ph.D. (1996) degrees in zoology from the University of Toronto, Canada, under the supervision of Yoshio Masui. Before his appointment as a Scientific Investigator at VARI in April 1999, he was a postdoctoral fellow in the laboratory of George Vande Woude in the Molecular Oncology Section of the Advanced BioScience Laboratories–Basic Research Program at the National Cancer Institute–Frederick Cancer Research and Development Center, Maryland.

Alfano, R.W., S.H. Leppla, S. Liu, T.H. Bugge, J.M. Ortiz, T.C. Lairmore, N. Duesbery, I.C. Mitchell, F. Nwariaku, and A. Frankel. 2010. Inhibition of tumor angiogenesis by the matrix metalloproteinase–activated anthrax lethal toxin in an orthotopic model of anaplastic thyroid carcinoma. Mol. Cancer Ther. 9(1): 190-201.  PubMed   Article  

Duesbery, N. In Press. From bark to bedside — dogs point to cancers' causes. Discoveries.   PubMed  

Alfano, R.W., S.H. Leppla, S. Liu, T.H. Bugge, C.J. Meininger, T.C. Lairmore, A.F. Mulne, S.H. Davis, N.S. Duesbery, and A.E. Frankel. 2009. Matrix metalloproteinase–activated anthrax lethal toxin inhibits endothelial invasion and neovasculature formation during in vitro morphogenesis. Mol. Cancer Res. 7(4): 452–461.  PubMed   Article  

Bromberg-White, J.L., E. Boguslawski, and N.S. Duesbery. 2009. Perturbation of mouse retinal vascular morphogenesis by anthrax lethal toxin. PLoS One 4(9): e6956.  PubMed   Article  

Frankel, A.E., S.-R. Kuo, D. Dostal, L. Watson, N.S. Duesbery, C.-P. Cheng, H.J. Cheng, W.-J. Tang, and S.H. Leppla. 2009. Pathophysiology of anthrax. Front. Biosci. 14(12): 4516–4524.  PubMed  

Alfano, R.W., S.H. Leppla, S. Liu, T.H. Bugge, N.S. Duesbery, and A.E. Frankel. 2008. Potent inhibition of tumor angiogenesis by the matrix metalloproteinase–activated anthrax lethal toxin: implication for broad anti-tumor efficacy. Cell Cycle 7(6): 745–749.  PubMed   Article  

Alfano, R.W., S.H. Leppla, S. Liu, T.H. Bugge, M. Herlyn, K.S. Smalley, J.L. Bromberg-White, N.S. Duesbery, and A.E. Frankel. 2008. Cytotoxicity of the matrix metalloproteinase–activated anthrax lethal toxin is dependent on gelatinase expression and B-RAF status in human melanoma cells. Mol. Cancer Ther. 7(5): 1218–1226.  PubMed   Article  

Bromberg-White, J.L., and N.S. Duesbery. 2008. Biological and biochemical characterization of anthrax lethal factor, a proteolytic inhibitor of MEK signaling pathways. Methods in Enzymology 438: 355-65.  PubMed   Article  

Ding, Y., E.A. Boguslawski, B.D. Berghuis, J.J. Young, Z. Zhang, K. Hardy, K. Furge, E. Kort, A.E. Frankel, R.V. Hay, J.H. Resau, and N.S. Duesbery. 2008. Mitogen-activated protein kinase kinase signaling promotes growth and vascularization of fibrosarcoma. Mol. Cancer Ther. 7(3): 648-658.  PubMed   Article  

Depeille, P., J.J. Young, E.A. Boguslawski, B.D. Berghuis, E.J. Kort, J.H. Resau, A.E. Frankel, and N.S. Duesbery. 2007. Anthrax lethal toxin inhibits growth of and vascular endothelial growth factor release from endothelial cells expressing the human herpes virus 8 viral G protein–coupled receptor. Clin. Cancer Res. 13(19): 5926-5934.  PubMed   Article  

Teh, B.T. and Duesbery, N.S. 2007. A tribute to George F. Vande Woude, a man of character: 2006 Scientific Symposium Winning the War against Cancer: from Genomics to Bedside and Back. Cancer Research 67(6): 2394-2395.  PubMed   Article  

Young, J.J., J.L. Bromberg-White, C.R. Zylstra, J.T. Church, E. Boguslawski, J.H. Resau, B.O. Williams, and N.S. Duesbery. 2007. LRP5 and LRP6 are not required for protective antigen–mediated internalization or lethality of anthrax lethal toxin. PLoS Path. 3(3): e27.  PubMed   Article  

Duesbery, N.S., and Teh, B.T. 2007. Cancer: biology and therapeutics--a tribute to George Vande Woude. Oncogene 26(9): 1258-1259.  PubMed   Article  

Depeille, P., Ding, Y., Bromberg-White, J., and Duesbery, N.S. 2007. MKK signaling and vascularization. Oncogene 26(9): 1290–1296.  PubMed   Article  

Abi-Habib, R.J., R. Singh, S.H. Leppla, J.J. Greene, Y. Ding, B. Berghuis, N.S. Duesbery, and A.E. Frankel. 2006. Systemic anthrax lethal toxin therapy produces regressions of subcutaneous human melanoma tumors in athymic nude mice. Clin. Cancer Res. 12(24): 7437–7443.  PubMed   Article  

Bodart, Jean-François L., and Nicholas S. Duesbery. 2006. Xenopus tropicalis oocytes: More than just a beautiful genome. In Xenopus Protocols: Cell Biology and Signal Transduction, X.J. Liu, ed. Methods in Cell Biology series, Totowa, N.J.: Humana Press.

Duesbery, Nick, and George Vande Woude. 2006. BRAF and MEK mutations make a late entrance. Science’s STKE 328: pe15.  PubMed   Article